Interleukins and Ischemic Stroke

Frontiers in Immunology

Siping Hu¹  Junjing Chen²  Yuntao Li³  Xinyao Hu³  Hua Zhu³  Xiaoxing Xiong³  Sheng Qiu⁴  Yao Sun⁴ 

[1] Department of Anesthesiology, The Affiliated Huzhou Hospital, Zhejiang University School of Medicine (Huzhou Central Hospital), Huzhou, China;Department of General Surgery, The Affiliated Huzhou Hospital, Zhejiang University School of Medicine (Huzhou Central Hospital), Huzhou, China;Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, China;Department of Neurosurgery, The Affiliated Huzhou Hospital, Zhejiang University School of Medicine (Huzhou Central Hospital), Huzhou, China;

关键词: interleukins;    ischemic stroke;    inflammation;    cytokines;    neuro-immune;   

DOI  :  10.3389/fimmu.2022.828447

来源: DOAJ

【 摘 要 】

Ischemic stroke after cerebral artery occlusion is one of the major causes of chronic disability worldwide. Interleukins (ILs) play a bidirectional role in ischemic stroke through information transmission, activation and regulation of immune cells, mediating the activation, multiplication and differentiation of T and B cells and in the inflammatory reaction. Crosstalk between different ILs in different immune cells also impact the outcome of ischemic stroke. This overview is aimed to roughly discuss the multiple roles of ILs after ischemic stroke. The roles of IL-1, IL-2, IL-4, IL-5, IL-6, IL-8, IL-9, IL-10, IL-12, IL-13, IL-15, IL-16, IL-17, IL-18, IL-19, IL-21, IL-22, IL-23, IL-32, IL-33, IL-34, IL-37, and IL-38 in ischemic stroke were discussed in this review.

【 授权许可】

Unknown