Serum levels of interleukin-2 differ between prostate cancer and benign prostatic hyperplasia

Jornal Brasileiro de Patologia e Medicina Laboratorial

关键词: interleukins;    cytokines;    inflammation;    prostate;    neoplasms;    prostatic hyperplasia, aging;   

DOI  :  10.1900/jbpml.2022.58.435

来源: DOAJ

【 摘 要 】

ABSTRACTObjectiveInvestigation onthe systemic inflammatory profile ofpatients affected by prostate cancer (PCa) or prostatic hyperplasia (BPH) may contribute to characterize the pathological profile as well as enable identification of markers and promote alternatives for appropriate, less invasive treatments.MethodsThis research compared serum levels of 10 classic inflammatory mediators among patients aged 50 years or older affected by PCa or BPH. For this, clinical, biochemical, metabolic, anthropometric and inflammatory aspects of each patient was considered.ResultsFrom the statistical analysis, a weakpositive correlation (r = 0.16) between IL-2 with serum total PSA values was found. In addition, median serum IL-2 values were three times higher in patients with PCa compared to BPH patients.ConclusionBy interpretation of current literature, we hypothesize that the activity of infiltratedtype M1 macrophages and activated cytotoxic cells in the neoplasm milieu might explain this increase of IL-2 as part of anendogenous anti-neoplastic response.

【 授权许可】

Unknown