Nullity of GSTT1/GSTM1 related to pesticides is associatedwith Parkinson's disease

Arquivos de Neuro-Psiquiatria

Marcela Augusta De Souza Pinhel²  Caroline Leiko Sado¹  Gabriela Dos Santos Longo¹  Michele Lima Gregorio²  Gisele Sousa Amorim²  Greiciane Maria Da Silva Florim²  Camila Montoro Mazeti²  Denise Poltronieri Martins²  Fabio De Nazare Oliveira¹  Marcelo Arruda Nakazone¹  Waldir Antonio Tognola¹  Doroteia Rossi Silva Souza¹ 

[1] ,FAMERPSao Jose do Rio Preto SP ,Brasil

关键词: Parkinson disease;    glutathione transferase;    polymorphism genetic;    xenobiotics;    doenca de Parkinson;    glutationa transferase;    polimorfismo genetico;    xenobioticos;   

DOI  :  10.1590/0004-282X20130076

来源: SciELO

【 摘 要 】

Genetic and environmental factors affect the pathogenesis of Parkinson's disease(PD). Genetic variants of the enzyme glutathione S-transferases (GST) may be relatedto the disease. This study aimed to evaluate the influence of genetic variants of GST(GSTT1/GSTM1) and their association with the exposure to environmental toxins in PDpatients. We studied 254 patients with PD and 169 controls. The GSTM1/GSTT1 variantswere analyzed by polymerase chain reaction. We applied the Fisher's exact test andthe χ2 test for statistical analysis (p<0.05). The present andabsence for GSTT1 and GSTM1 were similar in patients and controls. The null for GSTT1and GSTM1 (0/0) and exposure to pesticides prevailed in patients (18%) compared tocontrols (13%, p=0.014). This study suggests the association between PD and previousexposure to pesticides, whose effect may be enhanced in combination with null forGSTT1/GSTM1.

【 授权许可】

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