Exposure to pesticides and heterozygote genotype of GSTP1-Alw26I are associated to Parkinson's disease

Arquivos de Neuro-Psiquiatria

Gabriela S. Longo¹  Marcela S. Pinhel¹  Caroline L. Sado¹  Michele L. Gregório¹  Gisele S. Amorim¹  Greiciane S. Florim¹  Camila M. Mazeti¹  Denise P. Martins¹  Fábio N. Oliveira¹  Waldir A. Tognola¹  Marcelo A. Nakazone¹  Dorotéia R. S. Souza¹ 

关键词: glutathione transferase;    genetic polymorphism;    Parkinson disease;    xenobiotics;    glutationa transferase;    polimorfismo genético;    doença de Parkinson;    xenobióticos;   

DOI  :  10.1590/0004-282X20130060

来源: SciELO

【 摘 要 】

ObjectiveThis study aimed to analyze the frequency of GSTP1-Alw26I polymorphism and to estimate its association with toxic substances in Parkinson's disease (PD).MethodsA study group with 154 patients - subdivided into familial and sporadic PD groups - and 158 elderly individuals without the disease (control group) were evaluated. GSTP1-Alw26I polymorphism was analyzed by polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP).ResultsPatients were significantly more exposed to pesticides compared with the control group (p=0.0004), and the heterozygote genotype associated to exposure to pesticides also prevailed in patients (p=0.0001). Wild homozygote genotype was related to tobacco use (p=0.043) and alcoholism (p=0.033) in familial PD patients.ConclusionExposure to pesticides is associated to PD, whose effect can be enhanced when combined with the heterozygote genotype of GSTP1-Alw26I. Also, large genetic and environmental studies considering tobacco use, alcoholism, GSTP1 and PD are necessary to confirm our findings.

【 授权许可】

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