Arquivos de Neuro-Psiquiatria | |
Exposure to pesticides and heterozygote genotype of GSTP1-Alw26I are associated to Parkinson's disease | |
Gabriela S. Longo1  Marcela S. Pinhel1  Caroline L. Sado1  Michele L. Gregório1  Gisele S. Amorim1  Greiciane S. Florim1  Camila M. Mazeti1  Denise P. Martins1  Fábio N. Oliveira1  Waldir A. Tognola1  Marcelo A. Nakazone1  Dorotéia R. S. Souza1  | |
关键词: glutathione transferase; genetic polymorphism; Parkinson disease; xenobiotics; glutationa transferase; polimorfismo genético; doença de Parkinson; xenobióticos; | |
DOI : 10.1590/0004-282X20130060 | |
来源: SciELO | |
【 摘 要 】
ObjectiveThis study aimed to analyze the frequency of GSTP1-Alw26I polymorphism and to estimate its association with toxic substances in Parkinson's disease (PD).MethodsA study group with 154 patients - subdivided into familial and sporadic PD groups - and 158 elderly individuals without the disease (control group) were evaluated. GSTP1-Alw26I polymorphism was analyzed by polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP).ResultsPatients were significantly more exposed to pesticides compared with the control group (p=0.0004), and the heterozygote genotype associated to exposure to pesticides also prevailed in patients (p=0.0001). Wild homozygote genotype was related to tobacco use (p=0.043) and alcoholism (p=0.033) in familial PD patients.ConclusionExposure to pesticides is associated to PD, whose effect can be enhanced when combined with the heterozygote genotype of GSTP1-Alw26I. Also, large genetic and environmental studies considering tobacco use, alcoholism, GSTP1 and PD are necessary to confirm our findings.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
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