Action of selective serotonin reuptake inhibitor on aggressive behavior in adult rat submitted to the neonatal malnutrition

Arquivos de Neuro-Psiquiatria

Jairza Maria Barreto Medeiros²  Cristiano Mendes Da Silva²  Everton Botelho Sougey¹  José Audisio Costa²  Célia Maria M. Barbosa De Castro¹  Raul Manhães De Castro² 

[1] ,Universidade Federal de Pernambuco Departamento de Nutrição Recife PE ,Brasil

关键词: aggressive behavior;    malnutrition;    serotonin;    comportamento agressivo;    desnutrição;    serotonina;   

DOI  :  10.1590/S0004-282X2001000400004

来源: SciELO

【 摘 要 】

The effect of the malnutrition during suckling on the aggressiveness was investigated in adult rats treated or not with citalopram, a selective serotonin reuptake inhibitor (SSRI). The animals were divided into two groups according to the diet used: nourished group-- the rats received the control diet with 23% protein during the life; and malnourished group-- the rats had its mothers submitted to diet with 7.8% protein during suckling. At 120 days of age, each group was sub-divided according to the treatment: acute -- consisting a single i.p. injection of saline solution or 20-mg/Kg citalopram; chronic -- consisting the single injections (1 per day during 14 days) of saline or 20 mg/Kg citalopram. The acute or chronic treatment with SSRI reduces aggressive response in nourished rats, but not in malnourished ones. Thus, the malnutrition during the critical period of brain development seems to induce durable alterations in the function of the serotoninergic neurotransmission

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