APOE epsilon4 and Alzheimer's disease: positive association in a Colombian clinical series and review of the Latin-American studies

Arquivos de Neuro-Psiquiatria

Martine Jacquier²  Diana Arango¹  Elsa Villareal²  Orlando Torres²  Martha Lucia Serrano²  Marc Cruts¹  Patricia Montañes¹  Carlos Cano¹  Maria Nelcy Rodriguez¹  Sally Serneels¹  Christine Van Broeckhoven¹ 

[1] ,Instituto Nacional de Salud Group of Chronic Diseases Bogotá,Colombia

关键词: Alzheimer's disease;    APOE;    dementia;    risk factors;    ethnic groups;    Colombia;    enfermedad de Alzheimer;    APOE;    demencia;    factores de riesgo;    grupos étnicos;    Colombia;   

DOI  :  10.1590/S0004-282X2001000100004

来源: SciELO

【 摘 要 】

OBJECTIVE: As the strength of the association between the APOE epsilon4 allele and Alzheimer's disease (AD) varies across ethnic groups, we studied if there was such an association in Colombian patients. METHOD: We performed apolipoprotein E (APOE) genotyping in a clinical sample of 83 unrelated AD patients, predominantly late-onset (>65 yrs) including familial ( n =30) and sporadic AD cases (n= 53) diagnosed according to NINCDS-ADRDA criteria and assessed by a multi-disciplinary team. Control subjects (n = 44) had no significant cognitive impairment by medical interview and neuro-psychological testing. RESULTS: We found a high association (OR= 5.1 95%CI 1.9 -13.6) between APOE epsilon4 and AD, in this series with predominantly late-onset cases with familial aggregation in 24 cases (28.9%). A significant negative association was found between epsilon2 and AD (OR= 0.2 95% CI 0.05-0.75). CONCLUSION: Further population-based surveys in Colombia are warranted to precise a possible dose effect of APOE epsilon4.

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