Heparan sulfate proteoglycans: structure, protein interactions and cell signaling

Anais da Academia Brasileira de Ciências

Juliana L. Dreyfuss¹  Caio V. Regatieri¹  Thais R. Jarrouge¹  Renan P. Cavalheiro¹  Lucia O. Sampaio¹  Helena B. Nader¹ 

[1] ,Universidade Federal de São Paulo Departamento de Bioquímica São Paulo SP ,Brasil

关键词: glycosaminoglycans and protein interactions;    growth factors;    focal adhesion;    extracellular matrix;    cell cycle;    cell proliferation;    glicosaminoglicanos e interações com proteínas;    fatores de crescimento;    adesão focal;    matriz extracelular;    ciclo celular;    proliferação celular;   

DOI  :  10.1590/S0001-37652009000300007

来源: SciELO

【 摘 要 】

Heparan sulfate proteoglycans are ubiquitously found at the cell surface and extracellular matrix in all the animal species. This review will focus on the structural characteristics of the heparan sulfate proteoglycans related to protein interactions leading to cell signaling. The heparan sulfate chains due to their vast structural diversity are able to bind and interact with a wide variety of proteins, such as growth factors, chemokines, morphogens, extracellular matrix components, enzymes, among others. There is a specificity directing the interactions of heparan sulfates and target proteins, regarding both the fine structure of the polysaccharide chain as well precise protein motifs. Heparan sulfates play a role in cellular signaling either as receptor or co-receptor for different ligands, and the activation of downstream pathways is related to phosphorylation of different cytosolic proteins either directly or involving cytoskeleton interactions leading to gene regulation. The role of the heparan sulfate proteoglycans in cellular signaling and endocytic uptake pathways is also discussed.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License