Anais da Academia Brasileira de Ciências | |
Molluscicidal activity of 2-hydroxy-[1,4]naphthoquinone and derivatives | |
Celso A. Camara2  Tania M.s. Silva1  Thiago G. Da-silva1  Rodrigo M. Martins1  Ticiano P. Barbosa1  Angelo C. Pinto1  Maria D. Vargas1  | |
[1] ,Universidade Federal Rural de Pernambuco Departamento de Química Recife PE ,Brasil | |
关键词: Biomphalaria glabrata; Artemia salina; toxicity; quinones; schistosomiasis; molluscicidal activity; lawsone; 1; 4-naphthoquinone; Biomphalaria glabrata; Artemia salina; toxicidade; quinonas; esquistossomose; atividade moluscicida; lausona; 1; 4-naftoquinona; | |
DOI : 10.1590/S0001-37652008000200011 | |
来源: SciELO | |
【 摘 要 】
The toxic profile of lawsone (2-hydroxy-[1,4]naphthoquinone) and a series of [1,4]naphthoquinone derivatives was evaluated against the brine shrimp Artemia salina and against the mollusk Biomphalaria glabrata, the main transmitting vector of schistosomiasis in Brazil. Of the seventeen compounds tested nine fell below the threshold of 100 µg/mL set for potential molluscicidal activity by the World Health Organization. As a general rule derivatives with non-polar substituents presented the highest molluscicidal activities. These substances showed significant toxicity in A. salina lethality bioassay.
【 授权许可】
CC BY
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