Molluscicidal activity of 2-hydroxy-[1,4]naphthoquinone and derivatives

Anais da Academia Brasileira de Ciências

Celso A. Camara²  Tania M.s. Silva¹  Thiago G. Da-silva¹  Rodrigo M. Martins¹  Ticiano P. Barbosa¹  Angelo C. Pinto¹  Maria D. Vargas¹ 

[1] ,Universidade Federal Rural de Pernambuco Departamento de Química Recife PE ,Brasil

关键词: Biomphalaria glabrata;    Artemia salina;    toxicity;    quinones;    schistosomiasis;    molluscicidal activity;    lawsone;    1;    4-naphthoquinone;    Biomphalaria glabrata;    Artemia salina;    toxicidade;    quinonas;    esquistossomose;    atividade moluscicida;    lausona;    1;    4-naftoquinona;   

DOI  :  10.1590/S0001-37652008000200011

来源: SciELO

【 摘 要 】

The toxic profile of lawsone (2-hydroxy-[1,4]naphthoquinone) and a series of [1,4]naphthoquinone derivatives was evaluated against the brine shrimp Artemia salina and against the mollusk Biomphalaria glabrata, the main transmitting vector of schistosomiasis in Brazil. Of the seventeen compounds tested nine fell below the threshold of 100 µg/mL set for potential molluscicidal activity by the World Health Organization. As a general rule derivatives with non-polar substituents presented the highest molluscicidal activities. These substances showed significant toxicity in A. salina lethality bioassay.

【 授权许可】

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