Neurotransmitter regulation of neural development: acetylcholine and nicotinic receptors

Anais da Academia Brasileira de Ciências

AndrÉa S. TorrÃo¹  Luiz R.g. Britto¹ 

[1] ,Universidade de São Paulo Instituto de Ciências Biomédicas Departamento de Fisiologia e BiofísicaSão Paulo SP ,Brazil

关键词: acetylcholine;    development;    neurotransmitters;    nicotine;    nicotinic receptors;    acetilcolina;    desenvolvimento;    neurotransmissores;    nicotina;    receptores nicotínicos;   

DOI  :  10.1590/S0001-37652002000300008

来源: SciELO

【 摘 要 】

Several neurotransmitter systems have been related to developmental processes during the past decade. In this review, we discuss the evidence that the nicotinic acetylcholine receptors could have an additional function during development that may be unrelated to their role in cholinergic neurotransmission in the vertebrate brain. Both temporal expression data and in vitro and in vivo studies with nicotinic agonists and antagonists have provided direct support for a role of nicotinic receptors in neural developmental processes such as neurite outgrowth and differentiation. A similar picture has emerged for other neurotransmitter and receptor systems as well, which generates a new view of neural processes during both development and mature life.

【 授权许可】

CC BY   
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