Synthesis, physiochemical property and antimicrobial activity of novel quaternary ammonium salts

Journal of Enzyme Inhibition and Medicinal Chemistry

Feng Zhao¹  Guige Hou¹  Hongjuan Li¹  Wei Cong¹  Xianrui Xie¹  Wenyu Xin¹  Chunhua Wang¹ 

[1] School of Pharmacy, the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai, P. R. Chin;

关键词: 5-Phenyl-1,3,4-oxadiazole-2-thiol;    quaternary ammonium salts;    antibacterial activity;    antifungal activity;    cytotoxicity;   

DOI  :  10.1080/14756366.2017.1396456

来源: publisher

【 摘 要 】

Twenty-four novel 5-phenyl-1,3,4-oxadiazole-2-thiol (POT) analogues, benzo[d]oxazole-2-thiol, benzo[d]thiazole-2-thiol and 5-methyl-1,3,4-thiadiazole-2-thiol-substituted N,N-bis(2-hydroxyethyl) quaternary ammonium salts (QAS) (5a-d, 6a-d, 7a-d, 10a-d, 13a-d, 16a-d) were prepared and characterised by FTIR, NMR and elemental analysis. Part of target compounds (5d, 6d, 7d, 10d, 13d, 16d) displayed potent antimicrobial effect against ten common pathogens (S. aureus, α-H-tococcus, β-H-tococcus, E. coli, P. aeruginosa, Proteus vulgaris, Canidia Albicans, Cytospora mandshurica, Physalospora piricola, Aspergillus niger) and had relatively low cytotoxity against two human cell lines (HaCat and LO2). TEM and SEM images of E. coli and S. aureus morphologies treated with 7d showed that the antibacterial mechanism might be the QAS fixing on cell wall surfaces and puncturing to result in the release of bacterial cytoplasm. This study provides new information of QAS, which could be used to design novel antimicrobial agents applied in clinic or agriculture.

【 授权许可】

CC BY