Synthesis, crystal structure and biological activity of novel diester cyclophanes

Journal of the Brazilian Chemical Society

Fang, Xianwen¹  Northwest University, Xi'an, P. R. China¹  Yang, Meipan¹  Zhang, Pengfei¹  Yang, Bingqin¹  Cheng, Zhao¹ 

关键词: synthesis;    ester cyclophanes;    crystal;    antibacterial activity;    antifungal activity;   

DOI  :  

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

A series of novel diester cyclophanes was synthesized by esterification of 1,2-benzenedicarbonyl chloride with eight different diols under high dilution conditions. The structures of the compounds were verified by elemental analysis, 1H nuclear magnetic resonance (NMR), IR spectroscopy and high resolution mass spectrometry (HRMS). The crystal structures of two compounds were characterized by single crystal X-ray diffractometry (XRD). All the new cyclophanes were evaluated for biological activities and the results showed that some of these compounds have low antibacterial or antifungal activities.

【 授权许可】

Unknown