Synthesis and antimicrobial activities of a new class of 6-arylbenzimidazo[1,2-c]quinazolines

Journal of the Brazilian Chemical Society

Ravinder, Vadde¹  National Dong Hwa University, Hualien, Taiwan¹  Kakatiya University, India¹  Reddy, P. Muralidhar¹  Rohini, Rondla¹  Shanker, Kanne¹ 

关键词: 6-Arylbenzimidazo[1;    2-c]quinazolines;    synthesis;    antibacterial activity;    antifungal activity;   

DOI  :  10.1590/S0103-50532010000100009

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

A series of 6-arylbenzimidazo[1,2-c]quinazoline compounds (11-20) were synthesised by the condensation of 2-(o-aminophenyl)benzimidazole with different arylaldehydes, followed by oxidative cyclisation of the resulting 2-o-arylideneaminophenylbenzimidazoles (1-10). All the products were characterized via IR, 1H NMR, 13C NMR, MS and elemental analysis. The antimicrobial activities of all 6-arylbenzimidazo [1,2-c]quinazolines against three Gram-positive (S. aureus, B. subtilis, S. pyogenes), three Gram-negative (S. typhimurium, E. coli, K. pneumonia) bacteria and three fungal strains (A. niger, C. albicans, T. viridae) were evaluated. Among the compounds tested 13, 19 and 20 showed most potent inhibitory action against test organisms.

【 授权许可】

Unknown