Technology for the prevention of antimicrobial resistance and healthcare-associated infections; 2017 Geneva IPC-Think Tank (Part 2)

Antimicrobial Resistance & Infection Control

Enrique Castro-Sanchez¹  Raheelah Ahmad¹  Benjamin J. Park²  Denise Cardo²  Karl-Heinz Krause³  Eli Perencevich⁴  Carolyn Tarrant⁵  Sara Tomczyk⁶  Claire Kilpatrick⁶  Benedetta Allegranzi⁶  Julie Storr⁶  Didier Pittet⁷  Walter Zingg⁷  Andreas Widmer⁸ 

[1]0000 0001 2113 8111, grid.7445.2, National Institute for Health Research in Healthcare Associated Infection and Antimicrobial Resistance, Imperial College London, London, UK

[2]0000 0001 2163 0069, grid.416738.f, US Centers for Disease Control and Prevention, Atlanta, GA, USA

[3]0000 0001 2322 4988, grid.8591.5, Institute of Genetics and Genomics, University of Geneva, Geneva, Switzerland

[4]0000 0004 1936 8294, grid.214572.7, Carver College of Medicine, University of Iowa, Iowa City, USA

[5]0000 0004 1936 8411, grid.9918.9, Department of Health Sciences, University of Leicester, Leicester, UK

[6]0000000121633745, grid.3575.4, Infection Prevention and Control Global Unit, World Health Organization, Geneva, Switzerland

[7]Infection control programme and WHO collaborating center, University of Geneva Hospitals and Faculty of Medicine, 4 Rue Gabrielle Perret-Gentil, 1211, Geneva 14, Switzerland

[8]grid.410567.1, Infection Control Programme, University Hospitals of Basel, Basel, Switzerland

关键词: Technology;    Infection prevention and control;    Microbiome;    Whole genome sequencing;    Copper;    Hand hygiene;    CDC;    ECDC;    WHO;   

DOI  :  10.1186/s13756-019-0538-y

来源: publisher

【 摘 要 】

BackgroundThe high burden of healthcare-associated infections (HAIs) and antimicrobial resistance (AMR) is partially due to excessive antimicrobial use both in human and animal medicine worldwide. How can technology help to overcome challenges in infection prevention and control (IPC) and to prevent HAI and emerging AMR?MethodsIn June 2017, 42 international experts convened in Geneva, Switzerland to discuss four potential domains of technology in IPC and AMR: 1) role and potential contribution of microbiome research; 2) whole genome sequencing; 3) effectiveness and benefit of antimicrobial environmental surfaces; and 4) future research in hand hygiene.ResultsResearch on the microbiome could expand understanding of antimicrobial use and also the role of probiotics or even faecal transplantation for therapeutic purposes. Whole genome sequencing will provide new insights in modes of transmission of infectious diseases. Although it is a powerful tool for public health epidemiology, some challenges with interpretation and costs still need to be addressed. The effectiveness and cost-effectiveness of antimicrobially coated or treated environmental high-touch surfaces requires further research before they can be recommended for routine use. Hand hygiene implementation can be advanced, where technological enhancement of surveillance, technique and compliance are coupled with reminders for healthcare professionals.ConclusionsThe four domains of technological innovation contribute to the prevention of HAI and AMR at different levels. Microbiome research may offer innovative concepts for future prevention, whole genome sequencing could detect new modes of transmission and become an additional tool for effective public health epidemiology, antimicrobial surfaces might help to decrease the environment as source of transmission but continue to raise more questions than answers, and technological innovation may have a role in improving surveillance approaches and supporting best practice in hand hygiene.

【 授权许可】

CC BY