Development of a biophysical screening model for gestational hypertensive diseases

Journal of Biomedical Science

Wilfried Gyselaers¹  Sharona Vonck²  Dorien Lanssens²  Liesbeth Bruckers³  Kathleen Tomsin⁴  Anneleen S. Staelens⁴  Jolien Oben⁴ 

[1] 0000 0001 0604 5662, grid.12155.32, Faculty of Medicine and Life Sciences, Hasselt University, Agoralaan, 3590, Diepenbeek, Belgium;0000 0001 0604 5662, grid.12155.32, Department Physiology, Hasselt University, Agoralaan, 3590, Diepenbeek, Belgium;0000 0001 0604 5662, grid.12155.32, Faculty of Medicine and Life Sciences, Hasselt University, Agoralaan, 3590, Diepenbeek, Belgium;0000 0004 0612 7379, grid.470040.7, Department of Obstetrics & Gynaecology, Ziekenhuis Oost-Limburg, Schiepse Bos 6, 3600, Genk, Belgium;0000 0001 0604 5662, grid.12155.32, Interuniversity Institute for Biostatistics and statistical Bioinformatics, Hasselt University, Agoralaan, 3590, Diepenbeek, Belgium;0000 0004 0612 7379, grid.470040.7, Department of Obstetrics & Gynaecology, Ziekenhuis Oost-Limburg, Schiepse Bos 6, 3600, Genk, Belgium;

关键词: Gestational hypertensive diseases;    Hypertension;    Preeclampsia;    Screening;    Biophysical parameters;    Prediction;   

DOI  :  10.1186/s12929-019-0530-0

来源: publisher

【 摘 要 】

BackgroundTo investigate the possibility of using maternal biophysical parameters only in screening for the different types of gestational hypertensive diseases.MethodsA total of 969 pregnant women were randomly screened in first and second trimester, of which 8 developed Early-onset Preeclampsia, 29 Late-onset Preeclampsia, 35 Gestational Hypertension and 897 women had a normal outcome. An observational maternal hemodynamics assessment was done via standardized electrocardiogram-Doppler ultrasonography, Impedance Cardiography and bio-impedance, acquiring functional information on heart, arteries, veins and body fluid. Preliminary prediction models were developed to test the screening potential for early preeclampsia, late preeclampsia and gestational hypertension using a Partial Least Square Discriminant Analysis.ResultsA combined model using maternal characteristics with cardiovascular parameters in first and second trimester offers high screening performance with Area Under the Curve of 99,9% for Early-onset Preeclampsia, 95,3% for Late-onset Preeclampsia and 94% for Gestational Hypertension.ConclusionsUsing biophysical parameters as fundament for a new prediction model, without the need of biochemical parameters, seems feasible. However, validation in a large prospective study will reveal its true potential.

【 授权许可】

CC BY