Synthesis and biological evaluation of 3-arylcoumarins as potential anti-Alzheimer's disease agents

Journal of Enzyme Inhibition and Medicinal Chemistry

Jie Sun¹  Jie Yang¹  Pingping Zhang¹  Teng Liu¹  Xiaojing Wang¹  Yuheng Hu¹ 

[1] School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, China;Institute of MateriaMedica, Shandong Academy of Medical Sciences, Jinan, China;Key Laboratory for Biotech-Drugs Ministry of Health, Jinan, China;Key Laboratory for Rare & Uncommon Diseases of Shandong Province, Jinan, Chin;

关键词: 3-Arylcoumarin;    Alzheimer’s disease;    cholinesterase inhibitors;    monoamine oxidase inhibitors;    antioxidant activity;   

DOI  :  10.1080/14756366.2019.1574297

来源: publisher

【 摘 要 】

Alzheimer's disease, a neurodegenerative illness, has the extremely complex pathogenesis. Accumulating evidence indicates there is a close relationship between several enzymes and Alzheimer's disease. Various substituted 3-arylcoumarin derivatives were synthesised, and their in vitro activity, including cholinesterase inhibitory activity, monoamine oxidase inhibitory activity, and antioxidant activity were investigated. Most of the compounds exhibited high activity; therefore 3-arylcoumarin compounds have the potential as drug candidates for the treatment of Alzheimer's disease.

【 授权许可】

CC BY