A New Synthetic Route to Dihydrobenzopyran Via Tandem Demethylation Cyclisation

Molecules

Geetha Gopalakrishnan¹  Viswanathan Kasinath¹  N. D. Pradeep Singh¹  R. Thirumurugan¹  S. Shanmuga Sundara Raj¹ 

[1] ¹Centre for Natural Products, SPIC Science Foundation, Guindy, Chennai 600 032, India ²Department of Crystallography and Biophysics, University of Madras, Guindy Campus, Chennai-600 025, India ³X-ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, 11800 USM, Penang, Malaysia

关键词: Osthol;    pyranocoumarins;    demethylation;    cyclisation;    hard-soft interactions;   

DOI  :  10.3390/50600880

来源: mdpi

【 摘 要 】

A tandem demethylation-cyclisation reaction resulting in the formation of pyran rings using AlCl₃/EtSH reagent under mild reaction conditions is reported. X-ray diffraction studies on the intermediate support the suggested mechanism.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.