期刊论文详细信息
Antioxidants
Improving the Antioxidant Properties of Calophyllum inophyllum Seed Oil from French Polynesia: Development and Biological Applications of Resinous Ethanol-Soluble Extracts
Gaëtan Herbette1  Anne Mercier2  Mathieu Cassien2  Alice Asteian2  Marcel Culcasi2  Sylvia Pietri2  Sophie Thétiot-Laurent2  Emilie Ricquebourg2  Jean-Pierre Bianchini3  Phila Raharivelomanana3 
[1] CNRS, Spectropole FSCM, Aix Marseille Univ, 13397 Marseille, France;Campus Saint-Jérôme, CNRS, ICR, UMR 7273, SMBSO, Aix Marseille Univ, 13397 Marseille, France;IFREMER, ILM, IRD, EIO UMR 241, Univ Polynésie Française, 98702 Faa’a Tahiti, French Polynesia;
关键词: Calophyllum inophyllum L.;    Tamanu oil;    ethanol-soluble resin extracts;    lipophilic antioxidants;    phenolics;    pyranocoumarins;   
DOI  :  10.3390/antiox10020199
来源: DOAJ
【 摘 要 】

Tamanu oil from Calophyllum inophyllum L. has long been used in traditional medicine. Ethanol extraction was found the best strategy for recovering bioactive compounds from the resin part of Tamanu oil, yielding two neutral and acidic resins fractions with high phenolics, flavonoids and pyranocoumarins concentrations. A further cascade of LPLC/HPLC separations of neutral and acidic resin fractions allowed identifying fifteen metabolites, and among them, calanolide D and 12-oxocalanolide A (both in neutral fraction) were first identified from a natural source. All these extracts, subfractions and isolated metabolites demonstrated increased free radical scavenging, antioxidant, anti-inflammatory, antimicrobial and antimycobacterial activity compared to Tamanu oil and its de-resinated lipid phase. Overall, these results could promote resinous ethanol-soluble Tamanu oil extracts as a useful multifaceted and renewable medicinal resource.

【 授权许可】

Unknown   

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