Improving the Antioxidant Properties of Calophyllum inophyllum Seed Oil from French Polynesia: Development and Biological Applications of Resinous Ethanol-Soluble Extracts

Antioxidants

Gaëtan Herbette¹  Anne Mercier²  Mathieu Cassien²  Alice Asteian²  Marcel Culcasi²  Sylvia Pietri²  Sophie Thétiot-Laurent²  Emilie Ricquebourg²  Jean-Pierre Bianchini³  Phila Raharivelomanana³ 

[1] CNRS, Spectropole FSCM, Aix Marseille Univ, 13397 Marseille, France;Campus Saint-Jérôme, CNRS, ICR, UMR 7273, SMBSO, Aix Marseille Univ, 13397 Marseille, France;IFREMER, ILM, IRD, EIO UMR 241, Univ Polynésie Française, 98702 Faa’a Tahiti, French Polynesia;

关键词: Calophyllum inophyllum L.;    Tamanu oil;    ethanol-soluble resin extracts;    lipophilic antioxidants;    phenolics;    pyranocoumarins;   

DOI  :  10.3390/antiox10020199

来源: DOAJ

【 摘 要 】

Tamanu oil from Calophyllum inophyllum L. has long been used in traditional medicine. Ethanol extraction was found the best strategy for recovering bioactive compounds from the resin part of Tamanu oil, yielding two neutral and acidic resins fractions with high phenolics, flavonoids and pyranocoumarins concentrations. A further cascade of LPLC/HPLC separations of neutral and acidic resin fractions allowed identifying fifteen metabolites, and among them, calanolide D and 12-oxocalanolide A (both in neutral fraction) were first identified from a natural source. All these extracts, subfractions and isolated metabolites demonstrated increased free radical scavenging, antioxidant, anti-inflammatory, antimicrobial and antimycobacterial activity compared to Tamanu oil and its de-resinated lipid phase. Overall, these results could promote resinous ethanol-soluble Tamanu oil extracts as a useful multifaceted and renewable medicinal resource.

【 授权许可】

Unknown