Swern Oxidation of Bicyclo[2.2.1]hept-5-ene-2,3-diol and Its Pyrazine-fused Derivatives: An Improved Synthesis of Bicyclo[2.2.1]hept-5-ene-2,3-dione and An Unexpected Ring-Opening Reaction

Molecules

Tomoshige Kobayashi¹ 

[1] Department of Chemistry, Faculty of Science, Shinshu University, Matsumoto 390-8621, Japan

关键词: Swern oxidation;    vicinal cis-diol;    α-diketone;    ring-opening;    norbornene;    pyrazine;   

DOI  :  10.3390/50901062

来源: mdpi

【 摘 要 】

An improved synthesis of bicyclo[2.2.1]hept-5-ene-2,3-dione by Swern oxidation of bicyclo[2.2.1]hept-5-ene-2,3-diol, and an unexpected ring-opening reaction by the Swern oxidation of pyrazine-fused congeners are described.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.