Synthesis and Biological Evaluation of Triazole linked Thiazolidenone Glycosides

Acta Chimica Slovenica

Karthik Pulluri¹  Srinivas Kontham¹  Reddy Vasumathi¹  Santhosh Madavarapu¹  Sunitha Malladi¹  Sri Nivas Avula² 

[1] ;Lec in chemistry;

关键词: Swern oxidation;    click reaction;    cyclisation;    antimicrobial;    nematicidal activity;   

DOI  :  10.17344/acsi.2016.2727

来源: DOAJ

【 摘 要 】

In a one pot procedure , a series of novel Triazole linked thiazolidenone derivatives  8 a-g and 9 a-g  was prepared by condensation of  (3aR,5S,6R,6aR)- 6-((1-(4-fluorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-2,2-dimethyltetrahydro[2,3-d][1,3]dioxole-5- carbaldehyde  7 with mercapto acids and primary amines   in presence of ZnCl2  under both micro wave irradiation and conventional heating conditions. Compound  7 prepared  from di Acetone D- Glucose with oxidation followed by reduction , click reaction, primary acetonide deprotection and with oxidative cleavage .Characterization of new compounds has been done by means of IR, NMR, MS and elemental analysis. The nematicidal and anti bacterial activity of the compounds has also been evaluated.

【 授权许可】

Unknown