Toward Pyridine-Fused Selenium-Containing Antioxidants

Molecules

Tahli Fenner¹ 

[1] id="af1-molecules-09-00472">School of Chemistry, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria, Australia, 3010. Tel. [phone], Fax [phone]

关键词: Free radical;    homolytic substitution;    selenium;    antioxidants;   

DOI  :  10.3390/90600472

来源: mdpi

【 摘 要 】

Photolysis of the thiohydroximate ester derivative 21 of 2-carboethoxy-2-(2-(benzylseleno)pyridin-3-yl)tridecylcarboxylic acid (20) affords 2-dodecyl-2-carboethoxy-2,3-dihydroselenolo[2,3-b]pyridine (22) in 89% yield in a process presumably involving intramolecular homolytic substitution by a tertiary alkyl radical at selenium with loss of a benzyl radical. Work toward extending this methodology to the preparation of pyridine-fused selenium analogues of antioxidants is described.

【 授权许可】

Unknown   
© 2004 by MDPI (http://www.mdpi.org).