AFM study of a New Carrier Based on PLA and Salen Copolymers for Gene Therapy

Molecules

Véronique Nadeau¹ 

[1] id="af1-molecules-10-00105">Laboratoire de Nanotechnologie Pharmaceutique, Faculté de Pharmacie, Université de Montréal, CP 6128, succursale Centre Ville, Montreal, (Québec) H3C 3J7 Canada. Tel.: [phone], Fax: [phone]

关键词: AFM;    PLA;    Genetic Therapy;    Vector;    Salen;    Schiff base;   

DOI  :  10.3390/10010105

来源: mdpi

【 摘 要 】

The aim of this study was to synthesize novel biodegradable charged polymers to be used in DNA complexation for genetic delivery in different diseases. A new copolymer of PLA and complexed Schiff bases was synthesized in a several steps. This copolymer will be used as a nanocarrier. Also, AFM comparative studies in tapping mode were performed; on cationic copolymer and on PLA-Schiff base copolymer, on non-oriented and oriented film and on the DNA-cationic complex. The results indicated a difference in the topology and on phase picture of AFM film with or without cationic charge.

【 授权许可】

Unknown   
© 2005 by MDPI (http://www.mdpi.org).