Potent Skin Cancer Chemopreventing Activity of Some Novel Semi-synthetic Cembranoids from Marine Sources

Marine Drugs

Hesham Fahmy⁴  Jordan K. Zjawiony¹  Takao Konoshima³  Harukuni Tokuda²  Shabana Khan⁵ 

[1] Department of Pharmacognosy and National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677-1848, USA. Tel.: [phone], Fax: [phone]; E-mail:;Department of Molecular Biochemistry, Kyoto Prefectural University of Medicine, Kawaramachidori, Kamigyo-Ku, Kyoto 602-0841, Japan;Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan;Department of Pharmaceutical Sciences, South Dakota State University, Box 2202C, Brookings, SD 57007, USA. Tel.: [phone], Fax [phone], E-mail:;National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, The University of Mississippi, University, MS 38677-1848, USA

关键词: Cancer chemoprevention;    Skin cancer;    Cembranoids;    Sarcophine;    Sarcophyton glaucum;   

DOI  :  10.3390/md402028

来源: mdpi

【 摘 要 】

In the course of our continuing research in development and evaluation of novel skin cancer chemopreventive agents from marine sources, five semi-synthetic cembranoids derived from the marine natural product sarcophine, isolated from the soft coral Sarcophyton glaucum, were synthesized and shown to exhibit a remarkable chemopreventive activity in the in-vitro Epstein Barr Virus Early Antigen (EBV-EA) activation assay. These compounds were assayed in vivo using the two-stage carcinogenesis test of mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator, and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter by topical administration. They showed potent inhibition of both percentage incidence of skin tumor as well as the multiplicity of skin tumors per mouse compared to untreated controls.

【 授权许可】

Unknown   
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