Photoirradiation of Polycyclic Aromatic Hydrocarbons with UVA Light – A Pathway Leading to the Generation of Reactive Oxygen Species, Lipid Peroxidation, and DNA Damage

International Journal of Environmental Research and Public Health

Hongtao Yu¹  Qingsu Xia⁴  Jian Yan¹  Diogenes Herreno-Saenz²  Yuh-Shen Wu³  I-Wah Tang⁴ 

[1] Department of Chemistry, Jackson State University, Jackson, MS 39217, USA;Department of Pharmacology and Toxicology, School of Medicine, University of Puerto Rico, San Juan, Puerto Rico 00935;Hung Kuang University, Sha-Lu, Taichung, Taiwan, ROC;National Center for Toxicological Research, Jefferson, AR 72079, USA

关键词: Polycyclic aromatic hydrocarbons (PAHs);    photoirradiation;    lipid peroxidation;    DNA damage;    8-OHdG;   

DOI  :  10.3390/ijerph2006030045

来源: mdpi

【 摘 要 】

Polycyclic aromatic hydrocarbons (PAHs) are a class of genotoxic environmental contaminants. We have long been interested in determining the mechanisms by which PAHs induce genotoxicity. Although the metabolic activation of PAHs leading to biological activities has been well studied, the photo-induced activation pathway has seldom reported. In this paper, we review the study of photoirradiation of PAHs with UVA irradiation results in (i) cytotoxicity and DNA damage (ii) DNA single strand cleavage; (iii) formation of 8-hydroxy-2′-deoxyguanosine adduct (8-OHdG), and (iv) formation of lipid peroxidation. Evidence has been shown that these photobiological activities are mediated by reactive oxygen species (ROS).

【 授权许可】

CC BY   
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