In vitro antioxidant properties and induced G2/M arrest in HT-29 cells of dichloromethane fraction from Liriodendron tulipifera

Dynamic Chiropractic

关键词: Free radical;    lipid peroxidation;    protein oxidation;    DNA damage;    G2/M arrest.;   

DOI  :  10.5897/JMPR11.1125

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

The antioxidant and anti-proliferative effects of dichloromethane fraction from methanol extract ofLiriodendron tulipiferawere investigated in this study. Scavenging effects on the α,α-diphenyl-picrylhydrazyl (DPPH) and nitrite radicals, and protection against reactive oxygen species induced lipid, protein anddeoxyribonucleic acid(DNA) damage were evaluated. The dichloromethane fraction ofL. tulipiferaexhibited high antioxidant activities to scavenge DPPH and nitrite radicals, ferric reducing power and protection against biological macromolecular oxidative damage. Furthermore, the dichloromethane fraction ofL. tulipiferaexhibits the anti-proliferative activity and induction of the G2/M arrest in human colon tumor HT-29 cells. These results demonstrate potential antioxidant activities and anti-proliferative effect ofL. tulipifera, as an antioxidant for diseases caused by reactive oxygen species.

【 授权许可】

Unknown