Diverse Bacterial PKS Sequences Derived From Okadaic Acid-Producing Dinoflagellates

Marine Drugs

Roberto Perez¹  Li Liu¹  Jose Lopez¹  Tianying An¹ 

[1] ¹Department of Chemistry and Biochemistry, Florida International University, Miami, FL 33199, USA ²Oceanographic Center, Nova Southeastern University, Dania Beach FL 33004, USA

关键词: okadaic acid;    polyketide;    polyketide synthase;    biosynthesis;    Roseobacter.;   

DOI  :  10.3390/md6020164

来源: mdpi

【 摘 要 】

Okadaic acid (OA) and the related dinophysistoxins are isolated from dinoflagellates of the genus Prorocentrum and Dinophysis. Bacteria of the Roseobacter group have been associated with okadaic acid producing dinoflagellates and have been previously implicated in OA production. Analysis of 16S rRNA libraries reveals that Roseobacter are the most abundant bacteria associated with OA producing dinoflagellates of the genus Prorocentrum and are not found in association with non-toxic dinoflagellates. While some polyketide synthase (PKS) genes form a highly supported Prorocentrum clade, most appear to be bacterial, but unrelated to Roseobacter or Alpha-Proteobacterial PKSs or those derived from other Alveolates Karenia brevis or Crytosporidium parvum.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.