Molecules | |
Targeted Synthesis of1-(4-Hydroxyiminomethylpyridinium)-3-pyridiniumpropane Dibromide – A New Nerve Agent Reactivator | |
Kamil Kuca1  Kamil Musilek2  Martin Paar3  Daniel Jun1  Petr Stodulka1  Martina Hrabinova1  | |
[1] Center of Advanced Studies, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic;Department of Toxicology, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic;Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy, Hradec Kralove, Czech Republic | |
关键词: Acetylcholinesterase; reactivator; nerve agent; broad-spectrum reactivator; | |
DOI : 10.3390/12081964 | |
来源: mdpi | |
【 摘 要 】
Preparation of 1-(4-hydroxy-iminomethylpyridinium)-3-pyridiniumpropane dibromide is described. This compound represents a new acetylcholinesterase (AChE) reactivator, which has no substituents on the second pyridinium ring as found in other commonly used AChE reactivators. The reactivation ability of this reactivator was tested on tabun- and cyclosarin-inhibited AChE. According to the results obtained, the new compound (without substitution and with decreased molecule size) showed increased reactivation potency in case of cyclosarin inhibited AChE. A potent oxime for treatment of tabun and cyclosarin-caused intoxications was thus obtained via slight modification of the reactivator structure (compared to trimedoxime and K027).
【 授权许可】
Unknown
© 2007 by MDPI (http://www.mdpi.org).
【 预 览 】
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