Voltammetric Behavior of o-Nitrophenol and Damage to DNA

International Journal of Molecular Sciences

Da-Peng Zhang¹  Wei-Li Wu¹  Hai-Yan Long¹  Yun-Chun Liu¹ 

[1] id="af1-ijms-09-00316">College of Chemistry and Materials Science, Anhui Key Laboratory of Chemo-Biosensing, Anhui Normal University, Wuhu 241000, P.R. Chi

关键词: o-Nitrophenol;    DNA-modified GCE;    DNA damage;    Electrochemical reduction;   

DOI  :  10.3390/ijms9030316

来源: mdpi

【 摘 要 】

The electrochemical behavior of o-nitrophenol was studied in detail with a glassy carbon electrode (GCE). The dependence of peak potential on pH indicated that equivalent electrons and protons were involved in the process of o-nitrophenol reduction. The interaction of o-nitrophenol with calf thymus DNA was investigated by adding DNA to the o-nitrophenol solution and by immobilizing DNA on GCE, respectively. The peak current decrement and peak potential shift in presence of DNA indicated that o-nitrophenol could interact with DNA. The result was demonstrated that the in situ DNA damage was detected by differential pulse voltammetry after the o-nitrophenol was electrochemically reduced.

【 授权许可】

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