Impact of Deoxynivalenol on the Intestinal Microflora of Pigs

International Journal of Molecular Sciences

Yann J. Waché²  Charlotte Valat²  Gilbert Postollec²  Stephanie Bougeard²  Christine Burel²  Isabelle P. Oswald¹ 

[1] French Institute of Agricultural Research (INRA) – UR 66- Unité de Pharmacologie-Toxicologie, 180 chemin de Tournefeuille, 31027 Toulouse cedex 3 – France. E-Mail:;French Agency for Food Safety (AFSSA) – Zoopôle des côtes d’Armor, BP53, 22440 Ploufragan – France. E-Mails:

关键词: Mycotoxin;    Deoxynivalenol;    pigs;    intestinal microflora;    growth performance;    faeces;    anaerobic sulfite-reducing bacteria;    CE-SSCP;   

DOI  :  10.3390/ijms10010001

来源: mdpi

【 摘 要 】

Deoxynivalenol (DON), a mycotoxin produced by some Fusarium species, is a frequent contaminant of cereal. In the present study, 24 weanling piglets received either control feed or feed naturally contaminated with DON (2.8 mg/kg) for four weeks. Consumption of contaminated feed significantly reduced the animal weight gain during the first week of the experiment, but had a moderate effect on cultivable bacteria in the pig intestine. By contrast, changes in the intestinal microflora were observed by Capillary Electrophoresis Single-Stranded Conformation Polymorphism (CE-SSCP) in DON-exposed animals, suggesting an impact of this toxin on the dynamics of intestinal bacteria communities.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).