Molecular Docking Studies and Anti-Tyrosinase Activity of Thai Mango Seed Kernel Extract

Molecules

Saruth Nithitanakool¹  Pimolpan Pithayanukul¹  Rapepol Bavovada² 

[1] Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand;;Department of Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10300, Thailand; E-mail:

关键词: Mangifera indica L;    Molecular docking study;    Polyphenols;    Pentagalloylglucopyranose;    Tyrosinase inhibitor.;   

DOI  :  10.3390/molecules14010257

来源: mdpi

【 摘 要 】

The alcoholic extract from seed kernels of Thai mango (Mangifera indica L. cv. ‘Fahlun’) (Anacardiaceae) and its major phenolic principle (pentagalloylglucopyranose) exhibited potent, dose-dependent inhibitory effects on tyrosinase with respect to L-DOPA. Molecular docking studies revealed that the binding orientations of the phenolic principles were in the tyrosinase binding pocket and their orientations were located in the hydrophobic binding pocket surrounding the binuclear copper active site. The results indicated a possible mechanism for their anti-tyrosinase activity which may involve an ability to chelate the copper atoms which are required for the catalytic activity of tyrosinase.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.