Optimization and Comparison of Five Methods for Extraction of Coniferyl Ferulate from Angelica sinensis

Molecules

Jing-Jing Xie²  Jia Lu²  Zheng-Ming Qian²  Yue Yu²  Jin-Ao Duan¹ 

[1] Jiangsu Key Laboratory for TCM Formulae Research, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China;Institute of Chinese Medical Sciences, University of Macau, Macao, P.R. China

关键词: Hydrodistillation;    Supercritical fluid extraction;    Pressurized liquid extraction;    Angelica sinensis;    Coniferyl ferulate;    Sonication.;   

DOI  :  10.3390/molecules14010555

来源: mdpi

【 摘 要 】

Coniferyl ferulate, which is noted for its multiple pharmacological activities and chemical instability, is abundant in Angelica sinensis. In this paper, five methods, namely sonication extraction (SE), pressurized liquid extraction (PLE), supercritical fluid extraction (SFE), hydrodistillation (HD) and decoction (DC) for extraction of coniferyl ferulate, as well as ferulic acid, Z/E-ligustilide and Z/E-butylidenephthalide, from A. sinensis were optimized and compared. The results showed that the order of extraction efficiency was: PLE≈SE>SFE>>HD, DC. The compositions of the SE, PLE and SFE extracts, which had a high ratio of coniferyl ferulate, were very similar, while no coniferyl ferulate was obtained by HD and DC, though they had high selectivity for the extraction of ligustilide and ferulic acid, respectively. It was noteworthy that the content of ligustilide and coniferyl ferulate was not detectable in the decoction, the commonly used oral administration form of Traditional Chinese Medicines in clinical practice.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.