Sulphated Zirconia as an Eco-Friendly Catalyst in Acylal Preparation under Solvent-Free Conditions, Acylal Deprotection Assisted by Microwaves, and the Synthesis of Anhydro-Dimers of o-Hydroxybenzaldehydes

Molecules

Laura Nadxieli Palacios-Grijalva¹  Deysi Y. Cruz-González¹  Leticia Lomas-Romero¹  Eduardo González-Zamora¹  Gerardo Ulibarri¹ 

[1] ¹Departamento de Ciencias Básicas, UAM-A, Av. San Pablo, No. 180. C.P. 02200, México, D.F., Mexico ²Departamento de Química, UAM-I, San Rafael Atlixco, No. 186. C.P. 09340, México, D.F., Mexico ³Department of Chemistry & Biochemistry, Laurentian University, Sudbury, ON P3E2C6, Canada

关键词: sulphated zirconia;    solvent-free;    microwaves;    regioselective;    diacetates;   

DOI  :  10.3390/molecules14104065

来源: mdpi

【 摘 要 】

A solvent-free approach is described for the regioselective synthesis of acylals (1,1-diacetates) in shorter reaction times and higher yields, compared to conventional methodology using solvents. In the protection reaction of the o-hydroxybenzaldehyde the formation of acetyl compounds and anhydro-dimers was observed. The deprotection reaction involves microwave (MW) exposure of diluted reactants in the presence of solid sulphated zirconia (SZ) catalyst that can be easily recovered and reused. The sulphated zirconia was recycled several times without any loss of activity.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.