Simple and Expedient Access to Novel Fluorinated Thiazolo- and Oxazolo[3,2-a]pyrimidin-7-one Derivatives and Their Functionalization via Palladium-Catalyzed Reactions

Molecules

卷:27

Hassan Allouchi¹  Badr Jismy²  Wafa Blancou²  Mohamed Abarbri²  Soufiane Touil³ 

[1] Faculté de Pharmacie, Université de Tours, EA 7502 SIMBA, 31 Avenue Monge, 37200 Tours, France;

[2] Laboratoire de Physico-Chimie des Matériaux et des Electrolytes pour l’Energie (PCM2E), EA 6299, Avenue Monge, Faculté des Sciences, Université de Tours, Parc de Grandmont, 37200 Tours, France;

[3] Laboratoire des Composés Hétéro-Organiques et Matériaux Nanostructurés (LR18ES11), Faculté des Sciences de Bizerte, Université de Carthage, Zarzouna 7021, Tunisie;

关键词: thiazolo[3,2-a]pyrimidin-7-ones;    oxazolo[3,2-a]pyrimidin-7-ones;    fluorinated alkynes;    regioselective;    one-pot reaction;    Suzuki-Miyaura;   

DOI  :  10.3390/molecules27093013

来源: DOAJ

【 摘 要 】

An efficient, versatile, and one-pot method for the preparation of novel fluorinated thiazolo- and oxazolo[3,2-a]pyrimidin-7-ones is described from 2-aminothiazoles or 2-amino-oxazoles and fluorinated alkynoates. This transformation, performed under transition-metal-free conditions, offers new fluorinated cyclized products with good to excellent yields. Moreover, the functionalization of these N-fused scaffolds via the Suzuki-Miyaura and Sonogashira cross-coupling reactions led to the synthesis of highly diverse thiazolo- and oxazolo[3,2-a]pyrimidin-7-ones.

【 授权许可】

Unknown