Synthesis and Cytotoxicity of Novel Hexahydrothienocycloheptapyridazinone Derivatives

Molecules

Amedeo Pau¹  Gabriele Murineddu¹  Battistina Asproni¹  Caterina Murruzzu¹  Giuseppe E. Grella¹  Gérard A. Pinna¹  Maria M. Curzu¹  Irene Marchesi¹ 

[1] ¹Dipartimento Farmaco Chimico Tossicologico,Università di Sassari, Via Muroni 23/A, 07100 Sassari, Italy ²Department of Biomedical Sciences, Division of Biochemistry and Biophysics, and National Institute of Biostructures and Biosystems, University of Sassari, Viale San Pietro 43/b 07100 Sassari, Italy

关键词: pyridazinones;    synthesis;    cytotoxicity;   

DOI  :  10.3390/molecules14093494

来源: mdpi

【 摘 要 】

Designed as a new group of tricyclic molecules containing the thienocycloheptapyridazinone ring system, a number of 2N-substituted-hexahydrothienocycloheptapyridazinone derivatives were synthesized and their biological activity evaluated. Among the synthesized compounds, derivatives 7d and 7h were found to possess cytotoxic activity against non-small cell lung cancer and central nervous system cancer cell lines, respectively.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.