Synthesis and Cytotoxicity of Novel Hexahydrothienocycloheptapyridazinone Derivatives

Molecules

关键词: pyridazinones;    synthesis;    cytotoxicity;   

DOI  :  10.3390/molecules14093494

来源: DOAJ

【 摘 要 】

Designed as a new group of tricyclic molecules containing the thienocycloheptapyridazinone ring system, a number of 2N-substituted-hexahydrothienocycloheptapyridazinone derivatives were synthesized and their biological activity evaluated. Among the synthesized compounds, derivatives 7d and 7h were found to possess cytotoxic activity against non-small cell lung cancer and central nervous system cancer cell lines, respectively.

【 授权许可】

Unknown