Two New Jaspamide Derivatives from the Marine Sponge Jaspis splendens

Marine Drugs

Sherif S. Ebada³  Victor Wray²  Nicole J. de Voogd¹  Zhiwei Deng⁴  Wenhan Lin⁵ 

[1] National Museum of Natural History, PO Box 9517 2300 RA Leiden, The Netherlands; E-Mail:;Helmholtz Center for Infection Research, Inhoffenstrasse 7, D-38124 Braunschweig, Germany; E-Mail:;Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, Universitaetsstrasse 1, D-40225 Duesseldorf, Germany; E-Mail:;Analytical and Testing Center, Beijing Normal University, Beijing 100875, China; E-Mail:;State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China

关键词: Jaspis splendens;    jaspamide Q and R;    structure elucidation;    cytotoxic activity;   

DOI  :  10.3390/md7030435

来源: mdpi

【 摘 要 】

Two new jaspamide derivatives 2 and 3, together with the parent compound jaspamide (1) have been isolated from the marine sponge Jaspis splendens collected in Kalimantan (Indonesia). The structures of the new compounds were unambiguously elucidated based on 1D and 2D NMR spectral data, mass spectrometry and comparison with jaspamide (1). The new derivatives inhibited the growth of mouse lymphoma (L5178Y) cell line in vitro with IC₅₀ values of <0.1 μg/mL.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland