Iodocionin, a Cytotoxic Iodinated Metabolite from the Mediterranean Ascidian Ciona edwardsii

Marine Drugs

Anna Aiello¹  Ernesto Fattorusso¹  Concetta Imperatore¹  Marialuisa Menna¹ 

[1] Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli “Federico II”, Via D. Montesano 49, 80131, Napoli, Italy; E-Mails:

关键词: natural products;    iodinated metabolites;    cytotoxic activity;    structure elucidation;   

DOI  :  10.3390/md8020285

来源: mdpi

【 摘 要 】

Chemical investigation of the Mediterranean ascidian Ciona edwardsii has been performed, leading to the isolation of two halogenated compounds: a new tyrosineiodinated derivative iodocionin (1) and the relevant brominated analogue (2), previously isolated from a Caribbean sponge. The structure of the new compound 1 has been assigned on the basis of spectroscopic analysis. Both compounds were tested for cytotoxicity in vitro against two different cancer cell lines, L5178Y (mouse lymphoma) and PC-12 (rat pheochromocytoma). Iodocionin was shown to possess significant and selective activity against lymphoma cells with an IC₅₀ of 7.75 μg/mL.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland