New Bioactive Alkyl Sulfates from Mediterranean Tunicates

Molecules

Concetta Imperatore³  Anna Aiello³  Filomena D𠆚niello³  Paolo Luciano¹  Rocco Vitalone³  Rosaria Meli²  Giuseppina Mattace Raso² 

[1] C.S.I.A.S. (Centro Servizi Interdipartimentale di Analisi Strumentale), Università degli Studi di Napoli “Federico II”, Via D. Montesano 49, 80131, Napoli, Italy;Dipartimento di Farmacologia Sperimentale, Università degli Studi di Napoli “Federico II”, Via D. Montesano 49, 80131, Napoli, Italy;The NeaNat Group, Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli “Federico II”, Via D. Montesano 49, 80131, Napoli, Italy;

关键词: natural products;    alkyl sulfate;    cytotoxic activity;    structure elucidation;    ascidians;   

DOI  :  10.3390/molecules171112642

来源: mdpi

【 摘 要 】

Chemical investigation of two species of marine ascidians, Aplidium elegans and Ciona edwardsii, collected in Mediterranean area, led to isolation of a series of alkyl sulfates (compounds 1–5) including three new molecules 1–3. Structures of the new metabolites have been elucidated by spectroscopic analysis. Based on previously reported cytotoxic activity of these type of molecules, compounds 1–3 have been tested for their effects on the growth of two cell lines, J774A.1 (BALB/c murine macrophages) and C6 (rat glioma) in vitro. Compounds 1 and 2 induced selective concentration-dependent mortality on J774A.1 cells.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.