Chalcogenide Glass Optical Waveguides for Infrared Biosensing

Sensors

Marie-Laure Anne⁴  Julie Keirsse⁴  Virginie Nazabal⁴  Koji Hyodo³  Satoru Inoue⁷  Catherine Boussard-Pledel⁴  Hervé Lhermite¹  Joël Charrier⁵  Kiyoyuki Yanakata⁶  Olivier Loreal²  Jenny Le Person⁸  Florent Colas⁸  Chantal Compère⁸ 

[1] Institut d’Electronique et de Télécommunications de Rennes-Microelectronic, Université Rennes 1, 35042 Rennes, France;INSERM U522, IFR 140, University of Rennes 1, Rennes, France;Biomedical sensing and Imaging Group, Inst. for Human Science and Biomedical Engineering, National Institution of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan;Sciences Chimiques de Rennes, UMR 6226, Equipe Verres & Céramiques, Université Rennes 1, 35042 Rennes, France; E-Mail:;FOTON-CCLO, UMR 6082-ENSSAT, Université Rennes 1, 22305 Lannion, France;Dept. of Neurosurgery, Inst. of Clinical Medicine, University of Tsukuba, Tsukuba, Japan;National Institute for Materials Science, 1-1 Namiki, Tsukuba, 305-0041, Japan;IFREMER, ERT-Service Interfaces et Capteurs, BP 70 29280 Plouzané, France

关键词: chalcogenide;    optical sensor;    fibre;    planar waveguide;   

DOI  :  10.3390/s90907398

来源: mdpi

【 摘 要 】

Due to the remarkable properties of chalcogenide (Chg) glasses, Chg optical waveguides should play a significant role in the development of optical biosensors. This paper describes the fabrication and properties of chalcogenide fibres and planar waveguides. Using optical fibre transparent in the mid-infrared spectral range we have developed a biosensor that can collect information on whole metabolism alterations, rapidly and in situ. Thanks to this sensor it is possible to collect infrared spectra by remote spectroscopy, by simple contact with the sample. In this way, we tried to determine spectral modifications due, on the one hand, to cerebral metabolism alterations caused by a transient focal ischemia in the rat brain and, in the other hand, starvation in the mouse liver. We also applied a microdialysis method, a well known technique for in vivo brain metabolism studies, as reference. In the field of integrated microsensors, reactive ion etching was used to pattern rib waveguides between 2 and 300 μm wide. This technique was used to fabricate Y optical junctions for optical interconnections on chalcogenide amorphous films, which can potentially increase the sensitivity and stability of an optical micro-sensor. The first tests were also carried out to functionalise the Chg planar waveguides with the aim of using them as (bio)sensors.

【 授权许可】

CC BY   
© 2009 by the authors; licensee MDPI, Basel, Switzerland