Structural Investigation of Biologically Active Phenolic Compounds Isolated from European Tree Species

Molecules

Izabela Redzynia¹  Natasza E. Ziółkowska¹  Wiesław R. Majzner¹  Stefan Willför¹  Rainer Sjöholm¹  Patrik Eklund¹ 

[1] ¹Institute of Technical Biochemistry, Technical University of Łódź, ul. Stefanowskiego 4/10, 90-924 Łódź, Poland

关键词: phenolic compounds;    lignans;    flavonoids;    antioxidant potency;    crystal structure;    "host - guest" inclusion crystals;   

DOI  :  10.3390/molecules14104147

来源: mdpi

【 摘 要 】

X-ray structures of two compounds isolated from wood knots of coniferous trees, namely dihydrokaempferol (3,5,8,13-tetrahydroxyflavanon) and lariciresinol (3,14-dimetoxy-7,10-epoxylignan-4,15,19-triol), are presented here. Diffraction data for the Dihydrokaempferol crystals were collected on a CAD4 diffractometer and on a synchrotron for the lariciresinol crystal. The investigated compounds inhibit lipid peroxidation and lariciresinol is additionally a good scavenger of superoxide radicals. The structural data presented in this work provide a useful basis for designing more active compounds with potential use as antioxidants.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.