The Effect of the Aerial Part of Lindera akoensis on Lipopolysaccharides (LPS)-Induced Nitric Oxide Production in RAW264.7 Cells

International Journal of Molecular Sciences

Chung-Ping Yang⁴  Guan-Jhong Huang⁴  Hui-Chi Huang⁴  Yu-Chang Chen⁴  Chi-I Chang³  Sheng-Yang Wang⁵  Hsun-Shuo Chang²  Yen-Hsueh Tseng⁵  Shih-Chang Chien¹ 

[1] The Experimental Forest Management Office, National Chung-Hsing University, Taichung 402, Taiwan;Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan; E-Mail:;Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 912, Taiwan; E-Mail:;Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan; E-Mails:;Department of Forestry, National Chung Hsing University, Taichung 402, Taiwan; E-Mails:

关键词: Chinese herb;    Lindera akoensis;    butanolide;    lignans;    flavonoids;    anti-inflammatory;   

DOI  :  10.3390/ijms14059168

来源: mdpi

【 摘 要 】

Four new secondary metabolites, 3α-((E)-Dodec-1-enyl)-4β-hydroxy-5β-methyldihydrofuran-2-one (1), linderinol (6), 4′-O-methylkaempferol 3-O-α-l-(4″-E-p-coumaroyl)rhamnoside (11) and kaempferol 3-O-α-l-(4″-Z-p-coumaroyl) rhamnoside (12) with eleven known compounds—3-epilistenolide D₁ (2), 3-epilistenolide D₂ (3), (3Z,4α,5β)-3-(dodec-11-ynylidene)-4-hydroxy-5-methylbutanolide (4), (3E,4β,5β)-3-(dodec-11-ynylidene)-4-hydroxy-5-methylbutanolide (5), matairesinol (7), syringaresinol (8), (+)-pinoresinol (9), salicifoliol (10), 4″-p-coumaroylafzelin (13), catechin (14) and epicatechin (15)—were first isolated from the aerial part of Lindera akoensis. Their structures were determined by detailed analysis of 1D- and 2D-NMR spectroscopic data. All of the compounds isolated from Lindera akoensis showed that in vitro anti-inflammatory activity decreases the LPS-stimulated production of nitric oxide (NO) in RAW 264.7 cell, with IC₅₀ values of 4.1–413.8 μM.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland