8-Alkylcoumarins from the Fruits of Cnidium monnieri Protect against Hydrogen Peroxide Induced Oxidative Stress Damage

International Journal of Molecular Sciences

Chi-I Chang⁴  Wan-Chiao Hu⁶  Che-Piao Shen⁷  Ban-Dar Hsu⁷  Wei-Yong Lin³  Ping-Jyun Sung¹  Wei-Hsien Wang²  Jin-Bin Wu⁵ 

[1] Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan; E-Mail:;National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan; E-Mail:;Graduate Institute of Integrated Medicine, China Medical University, Taichung 404, Taiwan;Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 912, Taiwan; E-Mail:;Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung 404, Taiwan; E-Mail:;Department of Chemistry, National Taiwan University, Taipei 106, Taiwan; E-Mail:;Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu 300, Taiwan; E-Mails:

关键词: Chinese herb;    Cnidium monnieri;    8-alkylcoumarin;    oxidative stress;   

DOI  :  10.3390/ijms15034608

来源: mdpi

【 摘 要 】

Three new 8-alkylcoumarins, 7-O-methylphellodenol-B (1), 7-methoxy-8-(3-methyl-2,3-epoxy-1-oxobutyl)chromen-2-one (2), and 3′-O-methylvaginol (3), together with seven known compounds (4–10) were isolated from the fruits of Cnidium monnieri. Their structures were determined by detailed analysis of spectroscopic data and comparison with the data of known analogues. All the isolates were evaluated the cytoprotective activity by MTS cell proliferation assay and the results showed that all the three new 8-alkylcoumarins exhibited cytoprotective effect on Neuro-2a neuroblastoma cells injured by hydrogen peroxide.

【 授权许可】

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© 2014 by the authors; licensee MDPI, Basel, Switzerland