Coumarins from the Herb Cnidium monnieri and Chemically Modified Derivatives as Antifoulants against Balanus albicostatus and Bugula neritina Larvae

International Journal of Molecular Sciences

Zhan-Chang Wang¹  Dan-Qing Feng² 

[1] State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen 361005, China; E-Mail:;Department of Marine Technology and Ocean Engineering, College of Oceanography and Environmental Science, Xiamen University, Xiamen 361005, China; E-Mail:

关键词: antifouling activity;    Cnidium monnieri;    coumarins;    osthole;    structure-activity relationship;   

DOI  :  10.3390/ijms14011197

来源: mdpi

【 摘 要 】

In the search for new environmental friendly antifouling (AF) agents, four coumarins were isolated from the herbal plant Cnidium monnieri, known as osthole (1), imperatorin (2), isopimpinellin (3) and auraptenol (4). Furthermore, five coumarin derivatives, namely 8-epoxypentylcoumarin (5), meranzin hydrate (6), 2′-deoxymetranzin hydrate (7), 8-methylbutenalcoumarin (8), and micromarin-F (9) were synthesized from osthole. Compounds 1, 2, 4, 7 showed high inhibitory activities against larval settlement of Balanus albicostatus with EC₅₀ values of 4.64, 3.39, 3.38, 4.67 μg mL⁻¹. Compound 8 could significantly inhibit larval settlement of Bugula neritina with an EC₅₀ value of 3.87 μg mL⁻¹. The impact of functional groups on anti-larval settlement activities suggested that the groups on C-5′ and C-2′/C-3′ of isoamylene chian could affect the AF activities.

【 授权许可】

CC BY   
© 2013 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.