New Coumarins and Anti-Inflammatory Constituents from the Fruits of Cnidium monnieri

International Journal of Molecular Sciences

Tzong-Huei Lee⁵  Yuan-Chih Chen²  Tsong-Long Hwang⁴  Chih-Wen Shu³  Ping-Jyun Sung¹  Yun-Ping Lim⁶  Wen-Lung Kuo⁷ 

[1] National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan; E-Mail:;Department of Pharmacy & Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan; E-Mail:;Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan; E-Mail:;Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan; E-Mail:;Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei 110, Taiwan; E-Mail:;School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan; E-Mail:;Chung-Jen College of Nursing, Health Science and Management, Chiayi 600, Taiwan; E-Mail:

关键词: Cnidium monnieri;    umbelliferae;    coumarins;    structure elucidation;    anti-inflammatory activity;   

DOI  :  10.3390/ijms15069566

来源: mdpi

【 摘 要 】

The fruit of Cnidium monnieri is commercially used as healthcare products for the improvement of impotence and skin diseases. Three new coumarins, 3'-O-methylmurraol (1), rel-(1'S,2'S)-1'-O-methylphlojodicarpin (2), and (1'S,2'S)-1'-O-methylvaginol (3), have been isolated from the fruits of C. monnieri, together with 14 known compounds (4–17). The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 1, 4–12, and 14–17 exhibited inhibition (IC₅₀ ≤ 7.31 µg/mL) of superoxide anion generation by human neutrophils in response to formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B (fMLP/CB). Compounds 7, 9–11, 15, and 17 inhibited fMLP/CB-induced elastase release with IC₅₀ values ≤7.83 µg/mL. This investigation reveals that bioactive isolates (especially 6, 7, 14, and 17) could be further developed as potential candidates for the treatment or prevention of various inflammatory diseases.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.