A CMOS Time-Resolved Fluorescence Lifetime Analysis Micro-System

Sensors

Bruce R. Rae³  Keith R. Muir³  Zheng Gong²  Jonathan McKendry²  John M. Girkin¹  Erdan Gu²  David Renshaw³  Martin D. Dawson² 

[1] Department of Physics, Durham University, South Road, Durham, DH1 3LE, UK; E-Mail:;Institute of Photonics, University of Strathclyde, 106 Rottenrow, Glasgow, G4 0NW, UK; E-Mails:;Institute for Integrated Micro and Nano Systems, The School of Engineering, The University of Edinburgh, The King's Buildings, Mayfield Road, Edinburgh, EH9 3JL, UK; E-Mails:

关键词: CMOS;    single-photon avalanche diodes;    GaN;    micro light-emitting diodes (micro-LEDs);    fluorescence lifetime;    micro-system;   

DOI  :  10.3390/s91109255

来源: mdpi

【 摘 要 】

We describe a CMOS-based micro-system for time-resolved fluorescence lifetime analysis. It comprises a 16 × 4 array of single-photon avalanche diodes (SPADs) fabricated in 0.35 μm high-voltage CMOS technology with in-pixel time-gated photon counting circuitry and a second device incorporating an 8 × 8 AlInGaN blue micro-pixellated light-emitting diode (micro-LED) array bump-bonded to an equivalent array of LED drivers realized in a standard low-voltage 0.35 μm CMOS technology, capable of producing excitation pulses with a width of 777 ps (FWHM). This system replaces instrumentation based on lasers, photomultiplier tubes, bulk optics and discrete electronics with a PC-based micro-system. Demonstrator lifetime measurements of colloidal quantum dot and Rhodamine samples are presented.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.