期刊论文详细信息
Molecules
Regioselective Synthesis of New 2-(E)-Cyano(thiazolidin-2-ylidene)thiazoles
Mehdi Bakavoli1  Hamid Beyzaie1  Mohammad Rahimizadeh1  Hossein Eshghi1 
[1] 1Department of Chemistry, School of Sciences, Ferdowsi University of Mashhad, 91775-1436 Mashhad, Iran 2Department of Chemistry, School of Science, Islamic Azad University, Mashhad Branch, Mashhad, Iran
关键词: thiazole;    thiazolidine;    Hantzsch’s synthesis;    heterocyclization;    regioselective synthesis;    X-ray crystallography;   
DOI  :  10.3390/molecules14114849
来源: mdpi
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【 摘 要 】

Cyclocondensation of 2-[bis(methylthio)methylene]malononitrile (1) and cysteamine (2) afforded 2-(thiazolidin-2-ylidene)malononitrile (3). This compound on treatment with NaSH gave the corresponding thioamide derivative 4a in a regioselective manner on the basis of its single crystal X-ray diffraction analysis. Reaction of this compound with several α-bromocarbonyl compounds gave new 2-(E)-cyano(thiazolidin-2-ylidene)thiazoles 5a-g.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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