Regioselective Synthesis of New 2-(E)-Cyano(thiazolidin-2-ylidene)thiazoles

Molecules

Mehdi Bakavoli¹  Hamid Beyzaie¹  Mohammad Rahimizadeh¹  Hossein Eshghi¹ 

[1] ¹Department of Chemistry, School of Sciences, Ferdowsi University of Mashhad, 91775-1436 Mashhad, Iran ²Department of Chemistry, School of Science, Islamic Azad University, Mashhad Branch, Mashhad, Iran

关键词: thiazole;    thiazolidine;    Hantzsch’s synthesis;    heterocyclization;    regioselective synthesis;    X-ray crystallography;   

DOI  :  10.3390/molecules14114849

来源: mdpi

【 摘 要 】

Cyclocondensation of 2-[bis(methylthio)methylene]malononitrile (1) and cysteamine (2) afforded 2-(thiazolidin-2-ylidene)malononitrile (3). This compound on treatment with NaSH gave the corresponding thioamide derivative 4a in a regioselective manner on the basis of its single crystal X-ray diffraction analysis. Reaction of this compound with several α-bromocarbonyl compounds gave new 2-(E)-cyano(thiazolidin-2-ylidene)thiazoles 5a-g.

【 授权许可】

CC BY   
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