Regioselective synthesis of 2-[(E)-(benzo[d]thiazol-2(3H)-ylidene)(cyano)methyl]thiazoles

Heterocyclic communications

article

Mehdi Bakavoli¹  Hamid Beyzaei²  Mohammad Rahimizadeh¹  Hossein Eshghi¹ 

[1] Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad;Department of Chemistry, Faculty of Science, University of Zabol

关键词: α-bromocarbonyl compounds;    benzo[d]thiazole;    Hantzsch’s synthesis;    heterocyclization;    phosphorus pentasulfide;    regioselective synthesis;    thiazole;   

DOI  :  10.1515/hc.2011.031

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

Cyclocondensation of 2-[bis(methylthio)methylene]malononitrile and 2-amino-benzenthiol afforded 2-(benzo[ d ]thiazol-2-yl)malononitrile. This compound, on treatment with phosphorus pentasulfide, gave the corresponding thioamide derivative in a regioselective manner. Reaction of this compound with several α-bromocarbonyl compounds gave new 2-[( E )-(benzo[ d ]thiazol-2(3 H )-ylidene)(cyano)methyl]thiazoles.

【 授权许可】

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