期刊论文详细信息
Heterocyclic communications
Synthesis and transformations of 1-[2-(toluene-4-sulfonamido)ethyl]thiourea
article
Karine Eliazyan1  Ruzanna Hakobyan1  Vergush Pivazyan1  Emma Ghazaryan1  Aleksandr Yengoyan1 
[1] Armenian National Agrarian University;Armenian-Russian (Slavonic) State University
关键词: heterocyclization;    1;    3;    4-oxadiazoles;    1;    3;    4-thiadiazoles;    thiazole;    1-[2-(toluene-4-sulfonamido)ethyl]thiourea;   
DOI  :  10.1515/hc-2013-0005
学科分类:内科医学
来源: De Gruyter
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【 摘 要 】

Readily available 2-(toluene-4-sulfonylamino)ethylamine is a convenient starting material for a two-step synthesis of 1-[2-(toluene-4-sulfonamido)ethyl]thiourea ( 2 ). Heterocyclization of the thiourea moiety in 2 furnished a thiazole derivative 3 which was further functionalized into substituted thiazoles 4–6 . A series of 2-(thiazol-5-yl)-[1,3,4]oxadiazoles 8 , 10 and 2-(thiazol-5-yl)-[1,3,4]thiadiazoles 9 , 11 were obtained.

【 授权许可】

CC BY|CC BY-NC-ND   

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