Synthesis and transformations of 1-[2-(toluene-4-sulfonamido)ethyl]thiourea

Heterocyclic communications

article

Karine Eliazyan¹  Ruzanna Hakobyan¹  Vergush Pivazyan¹  Emma Ghazaryan¹  Aleksandr Yengoyan¹ 

[1] Armenian National Agrarian University;Armenian-Russian (Slavonic) State University

关键词: heterocyclization;    1;    3;    4-oxadiazoles;    1;    3;    4-thiadiazoles;    thiazole;    1-[2-(toluene-4-sulfonamido)ethyl]thiourea;   

DOI  :  10.1515/hc-2013-0005

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

Readily available 2-(toluene-4-sulfonylamino)ethylamine is a convenient starting material for a two-step synthesis of 1-[2-(toluene-4-sulfonamido)ethyl]thiourea ( 2 ). Heterocyclization of the thiourea moiety in 2 furnished a thiazole derivative 3 which was further functionalized into substituted thiazoles 4–6 . A series of 2-(thiazol-5-yl)-[1,3,4]oxadiazoles 8 , 10 and 2-(thiazol-5-yl)-[1,3,4]thiadiazoles 9 , 11 were obtained.

【 授权许可】

CC BY|CC BY-NC-ND