Dietary Supplementation with Conjugated Linoleic Acid Plus n-3 Polyunsaturated Fatty Acid Increases Food IntakeBrown Adipose Tissue in Rats

Nutrients

Alan A. Sneddon²  D. Vernon Rayner³  Sharon E. Mitchell³  Shabina Bashir²  Jung-Heun Ha³  Klaus W. Wahle¹  Amanda C. Morris³ 

[1] School of Medicine and Dentistry, Cancer Medicine Research Programme, University of Aberdeen, Aberdeen, AB25 2ZD, UK;Vascular Health Programme, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, AB21 9SB, UK;Obesity and Metabolic Health Programme, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, AB21 9SB, UK;

关键词: conjugated linoleic acid;    n-3 long chain polyunsaturated fatty acid;    white adipose tissue;    brown adipose tissue;    hypothalamus;    brain;   

DOI  :  10.3390/nu1020178

来源: mdpi

【 摘 要 】

The effect of supplementation with 1% conjugated linoleic acid and 1% n-3 long chain polyunsaturated fatty acids (CLA/n-3) was assessed in rats. Food intake increased with no difference in body weights. White adipose tissue weights were reduced whereas brown adipose tissue and uncoupling protein-1 expression were increased. Plasma adiponectin, triglyceride and cholesterol levels were reduced while leptin, ghrelin and liver weight and lipid content were unchanged. Hypothalamic gene expression measurements revealed increased expression of orexigenic and decreased expression of anorexigenic signals. Thus, CLA/n-3 increases food intake without affecting body weight potentially through increasing BAT size and up-regulating UCP-1 in rats.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.