FGF21 mediates the lipid metabolism response to amino acid starvation

Journal of Lipid Research

Francesc Villarroya¹  Diego Haro²  Joana Relat²  Albert Pérez-Martí²  Ana Luísa De Sousa-Coelho³  Pedro F. Marrero³  Elayne Hondares³  Francesc Ribas⁴ 

[1] Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona and CIBER Fisiopatología de la Obesidad y Nutrición, 08028 Barcelona, Spain;Institut de Biomedicina de la Universitat de Barcelona (IBUB), 08028 Barcelona, Spain;Departament de Bioquímica i Biologia Molecular, Facultat de Farmàcia, Universitat de Barcelona, 08028 Barcelona, Spain;Institut de Biomedicina de la Universitat de Barcelona (IBUB), 08028 Barcelona, Spain;

关键词: brown adipose tissue;    fibroblast growth factor 21;    leucine deprivation;    liver;    white adipose tissue;   

DOI  :  

来源: DOAJ

【 摘 要 】

Lipogenic gene expression in liver is repressed in mice upon leucine deprivation. The hormone fibroblast growth factor 21 (FGF21), which is critical to the adaptive metabolic response to starvation, is also induced under amino acid deprivation. Upon leucine deprivation, we found that FGF21 is needed to repress expression of lipogenic genes in liver and white adipose tissue, and stimulate phosphorylation of hormone-sensitive lipase in white adipose tissue. The increased expression of Ucp1 in brown adipose tissue under these circumstances is also impaired in FGF21-deficient mice. Our results demonstrate the important role of FGF21 in the regulation of lipid metabolism during amino acid starvation.

【 授权许可】

Unknown