Antinociceptive and Anti-Inflammatory Effects of Ethanolic Extracts of Glycine max (L.) Merr and Rhynchosia nulubilis Seeds

International Journal of Molecular Sciences

Joo Hyuk Yim¹  Ok-Hwan Lee³  Ung-Kyu Choi² 

[1]Korea Food Research Institute, Seongnam, Kyonggi, 463-746, Korea

[2] E-Mail:

[3]Pohang Center for Evaluation of Biomaterials, Pohang 790-834, Korea

[4] E-Mail:

[5]Department of Biomedical Science, CHA University, Seongnam, Kyonggi, 463-836, Korea

关键词: Glycine max;    Rhynchosia nulubilis;    anti-inflammatory activity;    anti-nociceptive activity;   

DOI  :  10.3390/ijms10114742

来源: mdpi

【 摘 要 】

The aim of this study was to assess the in vivo potential of ethanolic extracts of Glycine max (L.) Merr. (SoRiTae) and Rhynchosia nulubilis (Yak-Kong) seeds as natural anti-nociceptive and anti-inflammatory agents. To assess the anti-nociceptive and anti-inflammatory potential, the ethanolic extracts of SoRiTae and Yak-Kong seeds were tested in arachidonic acid-induced ear edema, carrageenan induced paw edema, formalin-induced licking time, acetic acid induced writhing and hot plate-induced thermal stimulation in mice. The administration of ethanolic extracts of SoRiTae and Yak-Kong seeds evoked a significant effect of anti-nociceptive and anti-inflammatory activities as compared to standards aminopyrine and indomethacin. The ear edema, paw edema, paw licking time, pain and writhes in mice were significantly reduced (p < 0.05) as compared to the control. The results obtained in this study indicate that both SoRiTae and Yak-Kong soybeans possesses potential anti-nociceptive and anti-inflammatory activities.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.